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The mouse models included lean mice (C57BL/6J and NSY.B6- a / a ), obese diabetic mice (NSY.B6- Ay / a ), proglucagon-deficient mice ( Gcg -/-), glucose-dependent insulinotropic polypeptide (GIP) receptor-deficient mice ( Gipr -/-), and ATP-sensitive potassium channel (KATP channel)-deficient mice ( Kcnj11 -/-)

Ryan, MD, is professor emerita at the Pennington Biomedical Research Center, Louisiana State University (LSU), in Baton Rouge, Louisiana.

Los pacientes que utilizan este medicamento han reportado mejoras en su control glucmico y una reduccin en el riesgo de complicaciones asociadas a la diabetes, como enfermedades cardiovasculares