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and trials in osteoarthritis where pain/inflammation measures improved, even before major weight loss

While some research has examined hair cortisol concentrations as a potential marker of chronic stress, this is not a recommended clinical test in US practice

The choice of alternative therapy should be individualised based on glycaemic control requirements, cardiovascular risk profile, renal function, patient preferences, and other clinical factors, in accordance with NICE guidance (NG28: Type 2 diabetes in adults: management)

Lancet Diabetes Endocrinol (2020) 8(5):392406