history of glp 1 agonists Frontiers Battle of GLP-1 delivery technologies

At present, combination with DPP-4 inhibitors is not recommended, despite the significant glycemic improvement, in view of the enhanced hypoglycemic effects

For all these effects, different benefits have been attributed to DPP-4is (including improvement of oxidative stress, inflammation, fibrosis and apoptosis, endothelial function, and tissue reparation), related to renal protection and a variety of cardiovascular and metabolic clinical conditions beyond T2D, including hypertension, calcified aortic valve disease, atherosclerosis, and heart failure (HF) [47,68]

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Importantly, individuals with T2DM continue to benefit from GLP- 1's glucose-lowering effects

Preclinical studies in diet-induced obesity rodent models are ongoing to evaluate its efficacy, safety, and tolerability as a potential therapy for type 2 diabetes and obesity