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An increase in serotonergic 5-HT2C receptor activity seemingly increases effects of GLP-1 agonism, and increased synaptic serotonin is simultaneously associated with decreased sexual response and desire

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After completion of the single-dose cohorts, an expansion panel randomized postmenopausal females at a ratio of 1:1:1:1 to receive IV doses of anti-ActA 10 mg/kg alone, anti-GDF8 6 mg/kg alone, co-administration of anti-GDF8 6 mg/kg + anti-ActA 10 mg/kg, or placebo

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