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are currently on a significant shortage, and that patients every month are having trouble," Reitano said

Before starting any GLP-1 medication, patients should undergo thorough medical evaluations to ensure these drugs are appropriate for their health conditions

In hEDS-associated neuropathic POTS where partial sympathetic denervation of the lower extremity vasculature produces blunted vasoconstriction, blood already pools in peripheral capacitance vessels on standing, stroke volume is structurally reduced, and the sympathetic nervous system is already operating near its compensation ceiling the additional vasodilatory and chronotropic load imposed by chronic dual incretin receptor agonism may have limited physiological reserve to absorb it

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