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Estos efectos pleiotrpicos explican por qu la GLP-1 se ha convertido en un objetivo teraputico importante para el tratamiento de la diabetes tipo 2 y, ms recientemente, para el manejo del sobrepeso y la obesidad

Medications such as GLP-1 or GLP-1/GIP are polypeptides that have several benefits, not only with weight reduction but can also assist in helping with fatty liver disease, reducing visceral adiposity (fat surrounding internal organs), and offering cardioprotection by helping reduce high cholesterol

A practical starting point: eat when hungry, stop when comfortably full, and aim for at least 100 grams of protein daily to preserve lean muscle mass during weight loss

Therefore, overall, the benefit of GLP-1RAs for heart failure has been difficult to confirm (Figure 1)

The drugs could produce huge benefits for people with obesity but also present a major cost challenge given the large percentage of the population that is eligible for them, the report said