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The pathogenesis of cerebral circulation disorders caused by chronic hyperglycemia is complex and includes mitochondrial dysfunction, neuroinflammation, impaired neurotransmitter systems, and vascular pathologies that lead to cognitive impairment, neurodegeneration, loss of synaptic plasticity, brain aging, and dementia [27]

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One study demonstrated that intraperitoneal injection of nesfatin-1 decreased food intake in a dose-dependent manner in mice and that c-Fos expression was significantly increased in the NTS, suggesting the role of VANs in this effect 228

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For example, exendin-4 at the concentration of 50 nM downregulated the expression of NF-B p65 in isolated human pancreatic cells [62]

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Opioid use disorder investigations

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