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Mechanisms of inflammatory responses and development of insulin resistance: how are they interlinked

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August 11, 2021

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Originally studied for metabolic and glycemic control, semaglutide has since demonstrated significant efficacy in promoting sustained weight reduction by targeting the physiological drivers of appetite, caloric intake, and metabolic efficiency

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Among these are the beta-cell hormone amylin and the intestinal L cell hormone glucagon-like peptide-1 (GLP-1)

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Surprisingly, in one recent study, robust expression of the GLP-1 receptor mRNA was also reported in human cardiac ventricles, but the exact localization of the GLP-1R protein could not be determined [613]

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