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In the placebo condition, participants with obesity showed an imbalance common in overeating: their brain's reward areas lit up when the cue signaled the impending milkshake, indicating heightened craving or wanting, but their neural response during the actual tasting was blunted, indicating reduced liking

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Good candidates typically have a BMI over 30, or a BMI of 27 or higher along with one or more weight-related health conditions such as type 2 diabetes, high blood pressure, or high cholesterol