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Changes in clinical parameters Significant differences were observed between the two groups in changes in several clinical parameters (BMI, SBP, HbA1c, LDL-C, CRP) during the follow-up period (Fig

Metabolic therapies such as GLP-1s primarily influence inflammation, mitochondrial function, and nutrient signaling, while other pharmacological or lifestyle strategies may act on telomere maintenance [16], senescence biology [17], or epigenetic regulation [18]
About half report they have experienced nausea and around one-third have experienced diarrhoea the two most common side effects associated with GLP-1s

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The regain pattern is not linear
