anti glp 1 drugs FDA says that the GLP-1 shortage is over How GLP-1 medications are transforming

Lilly's retatrutide reset the efficacy ceiling at 28.3% in TRIUMPH-1 in May

The bottom line: Our findings suggest that GLP-1RA and SGLT2i (and especially SGLT2i with the lowest number needed to treat (NNT) for nearly all study outcomes) may be the preferred glucose-lowering agents for cardiovascular risk reduction in patients at moderate risk for CVD, building on and consistent with existing RCT evidence in the high-risk population. This report highlights potential preference for GLP-1 drugs as a first-line treatment for Type 2 diabetes related to its cardioprotective effect

A patient who lost weight but developed fatigue, constipation, under-eating, or muscle weakness may need a different strategy than a patient who lost weight steadily, maintained strength, and improved lab markers

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Foster NC, Beck RW, Miller KM, Clements MA, Rickels MR, DiMeglio LA, et al