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Many users report that fatigue peaks in the first two to four days after each dose increase, then gradually improves over the next one to three weeks as the body adjusts

Side Effects The most common tirzepatide side effects include abdominal pain, burping, constipation, diarrhea, dyspepsia, fatigue, gastroesophageal reflux disease, hair loss, hypersensitivity reactions, injection site reactions, nausea, and vomiting, which affects 5% or more patients

Fatigue affects approximately 5% of people at 5 mg, 6% at 10 mg, and 7% at 15 mg

Waiting the recommended period gives your body time to stabilize blood sugar naturally, manage pain without medication conflicts, and begin normal eating patterns
