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More recent studies, also found that semaglutide reduced visceral adiposity and associated epicardial inflammation on imaging study, suggesting that GLP-1RAs may address both skin and fat-related inflammation in PsO patients with obesity and T2DM (58)
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Additionally, tirzepatide did not attenuate the reduction of sleeping metabolic rate or 24-h sedentary energy expenditure in comparison to baseline (though not significantly different than placebo), but significantly increased fat oxidation and decreased carbohydrate and protein oxidation as compared to placebo [57]
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