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An overview table of included studies is available in the Supplementary Material (S1) and online with options to filter the database ( The table includes information on first author and year of publication (1), paper title (2), whether the study was included in the meta-analysis (3) or systematic review (4), a tag indicating whether ghrelin or GLP-1 was investigated (5), specification of the hormonal assessment and/or manipulation (i.e., whether plasma acyl-, desacyl-, total ghrelin, GLP-1 was measured, which substance was administered (if any)) (6), type of reward phase assessed during fMRI (7), type of reward (e.g., food, money, alcohol) (8), and sample population(s) (9)

Some discussions also speculate about the way GLP-1based medicines affect appetite regulation, metabolism, and brain signalling

Statements that reflect projections or expectations of future financial or economic performance of the markets may be considered forward-looking statements

CrossRef Glucose-Sensing Receptor T1R3: A New Signaling Receptor Activated by Glucose in Pancreatic -Cells Itaru Kojima, Yuko Nakagawa, Kunihisa Hamano, Johan Medina, Longfei Li, Masahiro Nagasawa Biological & Pharmaceutical Bulletin.2015

Earlier this year, animal research published in eBioMedicine (February 2026) added to a growing body of evidence suggesting that medications acting on the GLP-1 system may one day play a role in treating alcohol use disorder ( AUD )