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Our studies revealed key signaling mechanisms underlying the role of GPR17 in regulating GLP-1 secretion and suggest future opportunities for pharmacologically targeting GPR17 with inverse agonists to maximize GLP-1 secretion ![Graphical Abstract][1] Graphical Abstract ### Competing Interest Statement The authors have declared no competing interest

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Learn what research grade tirzepatide means, why research grade GLP-1s are risky, and how patients and providers can stay compliant across the US.

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Semaglutide offers weight loss of 15% or more in patients with obesity, which was previously only achievable through surgical interventions.

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