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Real-World Cardiovascular Outcomes of Obesity Treatment With Tirzepatide Versus Semaglutide in Non-Diabetic Adults In obese individuals without diabetes, tirzepatide was associated with a lower risk of cardiovascular events, especially incident HF, compared with semaglutide,

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Stage 1 includes individuals with higher risk of developing dysglycaemia (defined based on validated country-specific risk scores than those with stage 0 or normal -cell function, whose high insulin resistance would be compensated by increased insulin production and glucose remains near normal despite gradual minimal decline in -cell function or mass