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In the current review, we discussed the dysregulation of IGF-1/GLP-1 signaling in neurodegenerative manifestations of ALS like a genetic anomaly, oligodendrocyte degradation, demyelination, glial overactivation, immune deregulation, and neuroexcitation

veterans suggests that popular GLP-1 drugs such as semaglutide may do far more than help with diabetes and weight lossthey could also fight addiction itself

Among these effects, increased insulin sensitivity, either by direct action on target organs or secondary to weight loss, might act synergistically with enhanced beta-cell function and insulin upregulation in the pancreas, collectively improving metabolic control.

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