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Lean mass decreased by 10.9% versus 2.6% with placebo

While some animal studies support clinical observations that these medications also help people reduce or stop alcohol and other drug use, formal human subjects research has yet to be conducted on the relationship between this class of medications and substance use

People who lose weight consistently across all six months experience better results than those who see dramatic drops in months 1-3 followed by prolonged plateaus

Medicina (Lithuania) 58(2):114

Renal and hepatic function
