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However, functional studies did detect the effects of GLP-1R in the hippocampus

For example, a prospective study of CVD in a multiethnic cohort of 4,014 individuals from six US communities, aged 45-84 years and free of clinical CVD at enrolment, recruited between 2000 and 2002, found that discrimination of the ACC/AHA PCE was suboptimal in MASLD (c-statistic 0.69), especially in moderate-to-severe steatosis (0.65), while calibration was poor and largely driven by overestimation in the highest-risk groups [17]

Here, the method was applied in a systematic fashion to the 31 amino acid peptide GLP-1 to generate a series of GLP-1-oligourea hybrids among which potent agonists of GLP-1R were identified

Furthermore, 77% of GLP-1treated patients achieved a 50% reduction in headache frequency, compared to 40% of controls ( p = 0.04)

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