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[269] Regular exercise during the day can improve sleep quality and may enhance responsiveness to melatonin, though vigorous exercise should be avoided close to bedtime

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In 2023, Juan P Frias and colleagues, in The Lancet, published the first phase two clinical trial of orforglipron, which investigated the use of a small-molecule oral GLP-1R agonist called orforglipron in type 2 diabetes, which can be taken at any time of the day without restrictions on food and water intake (Frias et al., 2023)

per 45 CFR 46, analyses of secondary, de-identified data are not human subjects research and do not require consent

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