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Moreover, the prevalence of PDA is low in the LSDM group, and the PDA risk is similar to other common cancers
Furthermore, in aged mice, it has been evidenced that BBR induced the relaxation of VSMCs with decreasing of blood pressure and also reduced vascular stiffness via suppression of the activity of Ca 2+ channel transient receptor potential vanilloid 4 (TRPV4) 144
The discontinuation was a business decision, and not due to safety or efficacy issues
doi: 10.1111/obr.13717, 54
