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Genetically-predicted GLP1R expression (the target of GLP-1 RAs) showed an inverse association with background [odds ratio (OR)=0.83, 95% CI, 0.710.97] and severe nonproliferative DR (OR=0.72, 95% CI, 0.530.98), and a non-significant association with overall (OR=0.97, 95% CI, 0.921.03) and proliferative DR (OR=0.98, 95% CI, 0.911.05)

The researchers analyzed data from a large, multi-institutional medical records database, including 73,483 adults taking GLP-1sincluding Semaglutide drugs like Ozempic & Wegovy, as well as Victoza (Liraglutide), Trulicity (Dulaglutide), or Byetta (Exenatide)and compared them with the same number of adults not taking the medications, tracking health outcomes for five years after treatment began

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