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Lixisenatide, a GLP-1R agonist, reduces neurofibrillary tangles and amyloid plaque load, and thereby ameliorates learning memory deficits in APP/PS1 mice (144, 157)

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They include type 2 diabetes, obesity, cardiovascular event risk reduction, obstructive sleep apnea, chronic kidney disease, and metabolic dysfunction-associated steatotic liver disease

Results from studies indicate that ghrelin also promotes lipid retention in adipocytes, which seems paradoxical given this hormones role as a hunger hormone, as during starvation lipids need to be released from stores and catabolised for ATP production, although it has also been argued that ghrelin protects fat stores from being utilised so that they can be used for ATP production during prolonged starvation