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Tetrahydropyran Analogs In research by Zhang et al., a novel series of trifluoromethyl-substituted tetrahydropyran derivatives was designed as potent DPP-4 inhibitors with an extended duration of action

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Introduction Glucagon like peptide-1 (GLP-1) is a 30 or 31 amino acid long peptide hormone mainly secreted by 3 tissues in the human body: enteroendocrine L cells in the distal intestine, alpha cells in the pancreas, and the central nervous system (1)

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