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Tirzepatide is the agonist of GLP-1 receptor and glucose-dependent insulinotropic polypeptide (GIP) receptor, which can reduce body weight and improve cardiac metabolism by subcutaneous injection once a week (Jastreboff et al 2022)

The randomisation schedule was generated by an online tool ( A designated research officer, who was not involved in data collection and analysis, was authorised to have access to the randomisation schedule and be responsible for the preparation of the study solutions, such that both the participants and the investigators involved in the study procedures were blinded to the treatments

Totally, 8,159 movies were obtained with a defocus range of -1.2 to -2.2 m

Under the action of unhealthy metabolic factors (obesity, diabetes), ER stress is initiated, and IRE-1 is activated, which in turn leads to the phosphorylation of IRS1 at the serine 307 residue by activating JNK, thereby impairing insulin signaling

A gut-selective dose of sitagliptin reduced lipid excursion and increased active GLP-1 levels in Dpp4 EC+/+ mice but not in Dpp4 EC/ mice, although plasma DPP-4 activity was decreased by approximately 20% in both genotypes (Figure 3, AD)