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Moderate to High), while dulaglutide, liraglutide, and semaglutide were effective in those with T2DM (Class IV

There are no waiting periods or restrictions around meals and other medications

During follow-up, 1,670 subjects in the GLP-1 cohort and 1,886 in the DPP-4 cohort developed epilepsy, or 2.35% vs 2.41%

473 It also improves myocardial energy metabolism, increases fatty acid oxidation in the myocardium, and improves myocardial energy supply

Specific keywords used in this search included GLP-1, GLP-1R, GLP-1RA, glycogen synthesis, energy metabolism, thermogenesis, liver, pancreas, skeletal muscle, adipose tissue, and BAT. Other searches were also conducted for foundational and background knowledge for topics such as disease states, treatments, and physiological processes relevant to this review and included terms such as type 2 diabetes mellitus, obesity, glycogen, glycogenesis, energy balance, metabolism, PASK, TGR5, microbiome, and GLP-1RA