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GLP-1s treat obesity in a couple of ways

furthermore, subcutaneous adipose tissue was reported to display a non-significant lower UCP-2 mRNA expression in obese compared to that in lean individuals

Best Pract Res Clin Endocrinol Metab 30:4557 Brom M, Oyen WJ, Joosten L, Gotthardt M, Boerman OC (2010) 68Ga-labelled exendin-3, a new agent for the detection of insulinomas with PET

Speculations aside, patients could still titrate their dose up gradually following standard dosing regimens before attempting any alternative regimens

Goossens GH, The Metabolic Phenotype in Obesity: Fat Mass, Body Fat Distribution, and Adipose Tissue Function