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A very small minority of people find that their fatigue doesn't get better or even gets worse

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It means 93-95% of people who start treatment can tolerate it well enough to continue, even if they experience some side effects along the way

The research-grade versus pharmaceutical-grade distinction becomes critical here

GLP-1 receptor agonist use led to a reduction in components of the composite MACE endpoint separately including risk of death from cardiovascular causes, fatal or non-fatal myocardial infarction, and fatal or non-fatal stroke