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Increasing scientific data on the obesity-pancreatic diseases conundrum also necessitates the need for integrating obesity-related markers into risk stratification and prognostic models, as well as exploring targeted therapeutic strategies in obesity-associated pancreatic disease.

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In this Review, the authors discuss neuromodulation therapies in relation to current knowledge of the nerve circuitry, provide insights into possible mechanisms and explore reasons for limited success and how effectiveness might be improved.