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In other CVOTs most patients received target dose (maximal tolerated dose) and no analysis was done regarding dose-dependent effects

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doi: 10.1016/j.cmet.2019.07.013

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The platform's published protocols and patient materials note that these medications are not recommended for patients who are pregnant, planning to become pregnant, or breastfeeding

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Many patients experience a temporary slowdown in weight loss after 36 months on GLP-1 therapy, a phenomenon called adaptive tolerance

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