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In other CVOTs most patients received target dose (maximal tolerated dose) and no analysis was done regarding dose-dependent effects

doi: 10.1016/j.cmet.2019.07.013

The platform's published protocols and patient materials note that these medications are not recommended for patients who are pregnant, planning to become pregnant, or breastfeeding

A.Abd El AalH
Many patients experience a temporary slowdown in weight loss after 36 months on GLP-1 therapy, a phenomenon called adaptive tolerance
