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A history of pancreatitis Pancreatitis (inflammation of the pancreas) has been reported in people on GLP-1 medications, though its uncommon and the absolute risk increase is small

A large retrospective cohort study involving 283,004 matched pairs found that tirzepatide users actually had a 65% lower incidence of malignant thyroid cancer compared to non-users, with a relative risk of 0.348

This information may decrease the risk of discontinuation because of nausea and may help patients to use the medication as a tool for weight loss by eating less

Elevated fasting insulin, visceral adiposity, non-alcoholic fatty liver disease, and chronic systemic inflammation are not merely cardiovascular or endocrine risk factors they represent a hostile cellular environment in which neoplastic transformation is more likely to occur, progress, and evade immune surveillance
