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It enrolled 17,604 adults aged 45 or older with a body mass index (BMI) of 27 kg/m2 or greater and preexisting CVD (prior MI, prior stroke or peripheral artery disease) without diabetes

Many people with type 2 diabetes also have hypertension (high blood pressure), a combination that significantly increases cardiovascular risk

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For example, many L-cells in the distal jejunum and ileum coexpress GLP-1 and PYY (14), whereas proximal L-cells can also produce GLP-1 (15), in addition to secreting CCK, GIP, neurotensin, or secretin (16)