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Keywords: Type 2 diabetes, Glucagon-like peptide-1, Glucagon-like peptide-1 receptor, GLP-1R agonist, GLP-1R agonist clinical trials Introduction A total of 387 million people worldwide have been diagnosed with diabetes, of which approximately 95% have type 2 diabetes (T2D)

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A post-mortem study of human pancreases demonstrated proliferative effects in those cases with GLP-1RA use, which were manifest by an increased mass of the pancreas along with increased frequency of PanIN1 and PanIN2 lesions compared to diabetes controls 23

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