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[129] The pens possibly contained insulin, and led to several people being hospitalised with hypoglycemia and seizures

In their statement to JAMA, William J

: Wegovy an adjunct to diet and exercise to reduce body weight an maintain weight reduction to reduce the risk of major adverse cardiovascular events (cardiovascular death, non-fatal myocardial infarction, or non-fatal stroke) in adults with established cardiovascular disease and either obesity or overweight

But neither of these mechanisms involves GLP-1 receptors, incretin hormones, or any of the pathways that GLP-1 receptor agonists target

A modest but significant LBM loss (2%) also occurred