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However, a Phase 2 clinical study evaluating ANS-6637 in treatment-seeking adults was terminated early due to concerns of liver toxicity (307), and efficacy results for a clinical trial using a hepatic ALDH2 mRNA inhibitor (DCR-AUD) are not yet publicly available (NCT05845398)

There are key limitations to the evidence

There was no plateau in weight loss at 46 weeks with the potential of further weight loss over a longer time period

Implementation of the BALANCE model in Medicare faces an uncertain future