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Consistent with our previous findings (20), oral gavage of systemically active doses of sitagliptin (10 mg/kg) inhibited plasma DPP-4 activity by approximately 85% when assessed 30 minutes after oral administration (Figure 1B)

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Finally, PKA inhibition or Epac1/2 inhibition alone only partially blocked liraglutide`s suppression of LPS-induced inflammation in H9c2 cardiac cells, but, together, PKA and Epac1/2 inhibition fully prevented liraglutide from reducing LPS-dependent inflammation

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