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The protocol for this trial and supporting CONSORT checklist are available as supporting information

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Due to their preclinical testing and lack of comparison with other dual receptor agonists such as tirzepatide, further studies are needed to determine whether the effects of these unimolecular compounds are superior to those of clinically tested drugs

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Furthermore, GLP-1R activation has been reported to suppress GABA_A receptor-mediated currents in retinal ganglion cells, indicating a broader role in modulating inhibitory neurotransmission [33]