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Between-study heterogeneity was very high (I = 99.21%) although sensitivity analysis revealed that the findings were robust

This umbrella review synthesizes the evidence for safety and efficacy GLP-1 receptor agonists on multiple outcomes including but not limited to metabolic, cardiovascular and renal outcomes.

In animal models, GLP-1 agonists have been shown to significantly delay the onset and severity of experimental autoimmune encephalopathy symptoms, as well as to increase nerve myelination and brain weight

**Survey of 291 adults who reported feeling lighter and more energetic after the Metamucil Two Week Challenge.