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A structured meal plan for tirzepatide users can help ensure adequate nutrition despite reduced appetite

Hold your next dose if you experience vomiting more than twice in one week, if nausea prevents you from eating adequate nutrition for more than 2 days, or if diarrhea becomes severe enough to cause dehydration concerns

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Finally, while this study cannot definitively differentiate between central nervous system and peripheral effects of GLP-1RAs on alcohol intake, it does provide evidence that there is a role for peripheral mechanisms, which should be examined in future studies

That is part of how it works