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This side effect typically subsides within 12 weeks, but many patients abandon treatment prematurely

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This suggests a dose-dependent effect

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First, cessation of GLP-1 treatment is associated with marked weight regain, as highlighted in a recent meta-analysis of eight randomised controlled trials which reported that participants taking semaglutide/tirzepatide regained 9.69 kg (95% CI 5.78, 13.60) over 4852 weeks [4]

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