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If sleep changes appear after a dose day, note the timing, meal pattern, and symptoms

Considering these findings observed across a large, real-world cohort, the researchers concluded that avoidance of semaglutide based solely on concerns regarding the risk of NAION may not be warranted, as its potential benefits for blood glucose control and cardiovascular health likely outweigh its potential risks.

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In a head-to-head trial published in the New England Journal of Medicine in May 2025, Mounjaro users lost 20.2 percent of body weight compared to 13.7 percent for Wegovy users

The safest option is through a licensed compounding pharmacy with a valid prescription