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Retatrutide promotes systemic fat loss without specifically targeting stubborn areas like lower abdominal or lower back fat

The available human data suggests significant regression toward baseline after discontinuation, which raises mechanistic questions about whether the compounds produce structural metabolic change or ongoing pharmacological modulation

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Liraglutide reduces hippocampal atrophy [26] and dopaminergic neuron loss [51], though its shorter half-life requires daily injections [36]