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At that point, metabolic adaptation is just beginning, lifestyle habits are still forming, and the biological drivers of regain are at their strongest

The SURMOUNT-1 trial published in the New England Journal of Medicine demonstrated remarkable results: participants achieved an average weight loss of 15% to 20.9% of their total body weight over 72 weeks, compared to just 3.1% in the placebo group

The fatty acylated co-agonist also produced a greater rate of insulin secretion compared to liraglutide during a hyperglycemic clamp in cynomolgus monkeys 40

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However, it is plausible that these hereditary genetic variations and epigenetic modifications dictate the baseline reactivity of the cutaneous microenvironment by priming local cell populations, and instigating the complex cellular crosstalk explored in the following section