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Tirzepatide also led to improvements in various cardiometabolic measures

Maybe they optimized their formulation

In clinical trials , participants taking a placebo lost around 2% of their body weight, compared to the 24% lost by those taking retatrutide

Tirzepatide, a coagonist of GIPR and GLP-1R, is characterized by greater efficacy in both glucose lowering and weight loss than can be achieved with current selective GLP-1RAs (16), while having a comparable adverse event profile

Instead, it works through hormonal pathways that require time and gradual adjustment
