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As depicted in Table 4, exenatide exhibited the broadest spectrum, with a total of 8 potential signals indicating GLP-1 RA-induced AP, ranging from pancreatic abscess (ROR 4.20, 95% CI 1.0317.03) to pancreatic phlegmon (ROR 84.53, 95% CI 21.86326.90)

Additionally, GLP-1R + neurons in the hindbrain locus coeruleus (LC) (83) partially mediate food avoidance behaviors of direct exenatide injection and peripherally injected semaglutide assessed by kaolin intake (84)

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If everything goes as planned, the FDA could approve orforglipron in 2026