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This included a less than 5% incidence rate of gastrointestinal adverse events and zero neuropsychiatric adverse events, which have been an issue with small-molecule CB1 inhibitors that have greater activity in the central nervous system

Further research should explore the underlying mechanisms of these adverse events, develop mitigation strategies, and assess differences across demographic groups

In the therapeutic landscape of pediatric obesity, GLP-1R agonists have emerged as particularly effective agents when compared with other available strategies

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Oral Wegovy should be taken first thing in the morning with no more than four ounces of plain water