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Our results were essentially robust to the different MR methods that make different assumptions about horizontal pleiotropy, suggesting that horizontal pleiotropy is unlikely to adequately explain our results

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Psoriasis is a chronic immune-mediated inflammatory skin disease driven by dysregulated interactions between keratinocytes and immune cells, particularly involving the interleukin (IL)-23/IL-17 axis and tumor necrosis factor (TNF)- signaling ( It is important to note that out of the thirteen dermatologic outcomes systematically evaluated in this target trial emulation, only threepsoriasis, pemphigus, and bullous pemphigoidmaintained statistical significance after rigorous adjustment for multiple testing using the BenjaminiHochberg procedure

Sarcopenia may coexist with cachexia (such as in some patients with heart failure), but it can also occur as an independent disease entity [6], which emphasizes the necessity of specialized identification and assessment of sarcopenia