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Although highly invasive, the most successful current treatment for obesity and diabetes is bariatric surgery 4 , highlighting the major impact of the gastrointestinal (GI) tract on energy and glucose homeostasis

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A search of the trial literature and registries finds retatrutide studied in obesity, in type 2 diabetes, in MASLD, in knee osteoarthritis with obesity, and in cardiovascular-disease populations but not in a cohort defined by PCOS, and not with PCOS-specific reproductive or androgen endpoints