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2022Dysregulated epicardial adipose tissue as a risk factor and potential therapeutic target of heart failure with preserved ejection fraction in diabetes

Rosenstock J, Ferrannini E

Hanefeld, M

The molecular mechanisms and signaling pathways by which GLP-1 improves sarcopenia.GLP-1 binds to GLP-1RA and exerts physiological effects through the PI3K/Akt and cAMP/PKA signaling pathways.GLP-1 mainly promotes muscle protein synthesis through the PI3K/Akt/mTORC1 pathway.The catabolism of muscle is mediated by specific transcription factors, such as FOXO proteins and NF-KB, and the activation of these transcription factors is triggered by extracellular stimuli or JAK-STAT signaling.GLP-1 can also improve mitochondrial function, reduce oxidative stress, and promote autophagy