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Although the overall structures of retatrutide-bound GLP-1R, GIPR and GCGR are highly similar, with C root mean square deviation (RMSD) values of 0.880.93 , unique structural features were noted at ECL1, ECL3 and the extracellular tips of TM1, TM3 and TM7, displaying receptor-specific positions and conformations

(2015) Functional consequences of glucagon-like peptide-1 receptor cross-talk and trafficking

This attenuation is explained in part by shifting complier composition: As GLP-1 diffusion expands, the marginal patients induced into treatment become progressively healthier

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But again, this is a general idea, and more research is needed to understand the specific effects